The type 2 diabetes mellitus (T2DM) drug semaglutide is effective for weight loss in non-diabetic, overweight or obese adults, when taken alongside a reduced-calorie diet and exercise, researchers have found. A randomised controlled trial published in the New England Journal of Medicine on 10 February 2021, which was sponsored by Novo Nordisk, was conducted across 129 sites in 16 countries in Asia, Europe, and North and South America. Researchers randomised 1,961 non-diabetic adults with either a body mass index (BMI) of 30 or greater, or a BMI of 27 or greater, with one or more weight-related coexisting conditions, in a 2:1 ratio to either 68 weeks of treatment with a weekly semaglutide injection (2.4mg) or placebo, plus lifestyle intervention. All participants received individual counselling sessions every four weeks to help them adhere to a reduced-calorie diet and increased physical activity. Overall, they found that participants who received semaglutide alongside lifestyle interventions had a mean weight loss of 14.9% from baseline, compared with a mean weight loss of 2.4% in the placebo group.
In addition, 86% of participants who received semaglutide, compared with 32% of those who received placebo, lost 5% or more of their baseline body weight, which the researchers said was a "widely used criterion of clinically meaningful response". "Weight loss with semaglutide stems from a reduction in energy intake owing to decreased appetite, which is thought to result from direct and indirect effects on the brain," the researchers wrote. "Weight loss with semaglutide was accompanied by greater improvements than placebo with respect to cardiometabolic risk factors, including reductions in waist circumference, blood pressure, glycated haemoglobin levels, and lipid levels; a greater decrease from baseline in C-reactive protein, a marker of inflammation; and a greater proportion of participants with normoglycemia," they added. They also highlighted that semaglutide improved physical functioning, which they said was "notable" given that being overweight or obese "significantly" impairs health-related quality of life. Semaglutide is a glucagon-like peptide-1 (GLP-1) analogue that is approved for the treatment of T2DM in adults and for reducing the risk of cardiovascular events in persons with T2DM and cardiovascular disease. Victoria Ruszala, a specialist diabetes pharmacist at North Bristol NHS Trust, said the results were to be expected considering the effectiveness of other GLP-1 drugs. Semaglutide is a more potent GLP-1 and therefore we would expect to see the same," she said. However, she said that semaglutide was the first drug to be seen to result in such a marked weight loss in participants. "No other drug (including liraglutide) has been able to show anywhere near this. In practice, we often see slightly lower numbers as patients don’t receive the same psychological and dietetic support; however, even 10kg is a game changer.
Science continues to prove that the old adage "you are what you eat" is profoundly true. This is because you have trillions of microorganisms living in your gut, which are directly responsible for nearly every aspect of your health. These microbes make up what’s called your "gut microbiota." They are especially influential in determining your likelihood of gaining excessive weight, becoming obese, MedicGLP Capsules and developing obesity-related diseases like diabetes, heart disease, and premature death. The gut microbiome (the expressed genes of your gut microbiota) plays a major role in your metabolism through energy production, storage, and expenditure. So, it’s no surprise that science has found a strong connection between gut microbiome imbalance and metabolic syndrome. Yikes! If you have the wrong mix of microbes, it could be making it tough for you to get your health on track! Did you know: Scientists can actually look at your gut microbiome composition and tell with 90% accuracy if you are obese or lean. That’s pretty impressive, isn’t it?
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